We had a blast with Fiasco. I got to ham it up, no one really knew which way the story was going to turn, and it was all horribly inappropriate in a wonderful way. My wife even got involved (she thought the game sounded really fun). We're all fairly convinced it's kind of a perfect game to play with non-gamers (my wife's pretty well a non-gamer and an introvert to boot). The Fiasco Companion even has tips on dulling the edges a bit, if you need something with a little less sex, drugs and violence.
Take a read at our actual play if you wanna know how our (hopefully first) session went.