Cheating again on this one and adding two:
I don't think I have ran this since my friend Kenny moved to Boston. Sad, really, given how much I love it.
The next one is...
I thoroughly enjoy the Cinematic Unisystem, and my favorite incarnation is the Angel RPG with the Buffy Magic Box supplement. Anytime I run this game, people tend to enjoy it, but it never lasts for more than a couple of episodes. I'm so frustrated I no longer even try. =/